Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations


This cell model shows aberrant Ca(2+) cycling characteristic of CPVT and in addition to DADs it displays EADs. This cell model for CPVT provides a platform to study basic pathology, to screen drugs, and to optimize drug therapy.

Authors Kujala K, Paavola J, Lahti A, Larsson K, Pekkanen-Mattila M, Viitasalo M, Lahtinen AM, Toivonen L, Kontula K, Swan H, Laine M, Silvennoinen O, Aalto-Setälä K
Journal PloS one
Publication Date 2012;7(9):e44660
PubMed 22962621
PubMed Central PMC3433449
DOI 10.1371/journal.pone.0044660

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