Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
Summary
Tissue-specific cells differentiated from patient-derived human induced pluripotent stem cells (hiPSC) are a relevant cellular model to study several diseases. We obtained a hiPSC line from skin fibroblasts of a patient affected by familial atrial fibrillation by nucleofection of non-integrating episomal vectors. The resulting hiPSC line displays a normal karyotype, expresses pluripotency surface markers and pluripotency genes, and differentiates into cells of the 3 germ layers. Therefore, it represents a reliable model to study the disease in a physiologically relevant cellular environment. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Martínez-Moreno R, Pérez-Serra A, Selga E, Carreras D, Aran B, Kuebler B, Scornik FS, Pérez GJ, Brugada R |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Dec;73:103239 |
| PubMed | 37922745 |
| DOI | 10.1016/j.scr.2023.103239 |