Miro1 Impairment in a Parkinson's At-Risk Cohort


There is a lack of reliable molecular markers for Parkinson's disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease onset. We have previously found that the mitochondrial protein Miro1 is resistant to mitochondrial depolarization-induced degradation in fibroblasts from a large number of PD patients and several at-risk individuals. Therefore, Miro1 has the potential to molecularly label PD populations. In order to determine whether Miro1 could serve as a molecular marker for the risk of PD, here we examine the Miro1 response to mitochondrial depolarization by biochemical approaches in induced pluripotent stem cells from a cohort of at-risk individuals. Our results show that the Miro1 phenotype is significantly associated with PD risk. We propose that Miro1 is a promising molecular marker for detecting both PD and at-risk populations. Tracking this Miro1 marker could aid in diagnosis and Miro1-based drug discoveries. Copyright © 2021 Nguyen, Bharat, Conradson, Nandakishore and Wang.

Authors Nguyen D, Bharat V, Conradson DM, Nandakishore P, Wang X
Journal Frontiers in molecular neuroscience
Publication Date 2021;14:734273
PubMed 34434090
PubMed Central PMC8381147
DOI 10.3389/fnmol.2021.734273

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