Generation of an integration-free induced pluripotent stem cell line, MURAi006-A, from a hemoglobin E/β-thalassemia patient harboring the β(E)/β(0) (Codon 17, A > T) compound heterozygous mutation
Summary
The HBB gene encodes the β-globin protein, one of the two main components of adult hemoglobin A (HbA) responsible for oxygen transport. β-thalassemia is a genetic disorder caused by mutations affecting β-globin chain synthesis, leading to reduced or absent β-globin production, impaired erythropoiesis, and generally results in anemia. In this study, the human-induced pluripotent stem cell line (hiPSC) MURAi006-A was generated from male fetal skin fibroblasts carrying both a β⁰-thalassemia mutation at codon 17 (A > T) and a codon 26 (G > A) HbE mutation using non-integrative reprogramming episomes. Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Innachai P, Pornratananont G, Satirapod C, Anurathapan U, Songdej D, Tangprasittipap A, Hongeng S |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Mar 26;85:103702 |
| PubMed | 40179812 |
| DOI | 10.1016/j.scr.2025.103702 |