Generation of iPSC line ICGi024-A from human skin fibroblasts of a patient with ring chromosome 18

Summary

Ring chromosome 18 is a rare chromosomal disorders that usually originate de novo and correlate with clinical manifestation: developmental delay as well as microcephaly, brain and ocular malformations, hypotonia and skeletal abnormalities. We generate iPSC clonal cell line ICGi024-A with pluripotency properties which were demonstrated in vitro by three germ layer differentiation capacity. ICGi024-A can be used for disease modeling and fundamental investigation of ring chromosome instability. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Khabarova AA, Pristyazhnyuk IE, Orlova PA, Nikitina TV, Kashevarova AA, Lopatkina ME, Belyaeva EO, Sukhanova NN, Nazarenko LP, Lebedev IN, Serov OL
Journal Stem cell research
Publication Date 2020 Nov 3;49:102076
PubMed 33212351
DOI 10.1016/j.scr.2020.102076

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