Generation of iPSC line ICGi024-A from human skin fibroblasts of a patient with ring chromosome 18
Summary
Ring chromosome 18 is a rare chromosomal disorders that usually originate de novo and correlate with clinical manifestation: developmental delay as well as microcephaly, brain and ocular malformations, hypotonia and skeletal abnormalities. We generate iPSC clonal cell line ICGi024-A with pluripotency properties which were demonstrated in vitro by three germ layer differentiation capacity. ICGi024-A can be used for disease modeling and fundamental investigation of ring chromosome instability. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Khabarova AA, Pristyazhnyuk IE, Orlova PA, Nikitina TV, Kashevarova AA, Lopatkina ME, Belyaeva EO, Sukhanova NN, Nazarenko LP, Lebedev IN, Serov OL |
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| Journal | Stem cell research |
| Publication Date | 2020 Dec;49:102076 |
| PubMed | 33212351 |
| DOI | 10.1016/j.scr.2020.102076 |