Human stem cell-derived neurons and astrocytes to detect novel auto-reactive IgG response in immune-mediated neurological diseases
Summary
Our unique hiPSC-based CBA allows for the testing of novel neuron-/astrocyte-reactive antibodies in patients with suspected immune-mediated neurological syndromes, and negative testing in established routine laboratories, opening new perspectives in establishing a diagnosis of such complex diseases. Copyright © 2024 Mathias, Perriot, Jones, Canales, Bernard-Valnet, Gimenez, Torcida, Oberholster, Hottinger, Zekeridou, Theaudin, Pot and Du Pasquier.
| Authors | Mathias A, Perriot S, Jones S, Canales M, Bernard-Valnet R, Gimenez M, Torcida N, Oberholster L, Hottinger AF, Zekeridou A, Theaudin M, Pot C, Du Pasquier R |
|---|---|
| Journal | Frontiers in immunology |
| Publication Date | 2024;15:1419712 |
| PubMed | 39114659 |
| PubMed Central | PMC11303155 |
| DOI | 10.3389/fimmu.2024.1419712 |