An induced pluripotent stem cells line (SDQLCHi014-A) derived from urine cells of a patient with ASD and hyperactivity carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene
Summary
Autism spectrum disorder (ASD) is a childhood-onset neurodevelopmental disorder challenged in social reciprocity and restrictive repetitive behaviors. Here, we generated an induced pluripotent stem cell (iPSC) line SDQLCHi014-A from a patient with ASD and hyperactivity, carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene by reprogramming urine cells with non-integrating vectors. SDQLCHi014-A have shown full pluripotency, differentiation capacity and genetic stability. This iPSC line provides a valuable resource to study the molecular mechanisms underlying ASD. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Yang X, Liu Y, Zhou T, Zhang H, Dong R, Li Y, Liu N, Liu Y, Gai Z |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2019 Dec;41:101635 |
| PubMed | 31707215 |
| DOI | 10.1016/j.scr.2019.101635 |