A heterozygous TTN (c. 79,684C>T) mutant human induced pluripotent stem cell line (ZZUNEUi023-A) generated from a Kazakh patient with dilated cardiomyopathy


Dilated cardiomyopathy (DCM) is a nonischaemic heart muscle disease with structural and functional myocardial abnormalities. TTN truncating mutations are a common cause of DCM, occurring in ∼25% of familial cases of DCM and in 18% of sporadic cases. In this study, we generated a human induced pluripotent stem cell line ZZUNEUi023-A from peripheral blood mononuclear cells of a Kazakh DCM patient with the p. Arg26562Ter (c. 79684C>T) mutation in TTN using non-integrative Sendai virus. This cell line expressed pluripotency markers, showed normal male karyotype and could differentiate into all three germ layers in vitro. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Li X, Wei W, Li X, Qi L, Lu S, Wei H, Liu Y, Dong J, Zhang C, Lin T
Journal Stem cell research
Publication Date 2021 Dec 2;57:102614
PubMed 34883393
DOI 10.1016/j.scr.2021.102614

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