Patient-specific induced pluripotent stem-cell models for long-QT syndrome

Summary

We generated patient-specific pluripotent stem cells from members of a family affected by long-QT syndrome type 1 and induced them to differentiate into functional cardiac myocytes. The patient-derived cells recapitulated the electrophysiological features of the disorder. (Funded by the European Research Council and others.)

Authors Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz KL
Journal The New England journal of medicine
Publication Date 2010 Oct 7;363(15):1397-409
PubMed 20660394
DOI 10.1056/nejmoa0908679

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