Patient-specific induced pluripotent stem-cell models for long-QT syndrome
Summary
We generated patient-specific pluripotent stem cells from members of a family affected by long-QT syndrome type 1 and induced them to differentiate into functional cardiac myocytes. The patient-derived cells recapitulated the electrophysiological features of the disorder. (Funded by the European Research Council and others.)
| Authors | Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz KL |
|---|---|
| Journal | The New England journal of medicine |
| Publication Date | 2010 Oct 7;363(15):1397-409 |
| PubMed | 20660394 |
| DOI | 10.1056/nejmoa0908679 |