Generation of induced pluripotent stem cell line (XDCMHi001-A) from an Ankylosing spondylitis patient with JAK2 mutation


Heredity is the major factor contributing to the susceptibility to ankylosing spondylitis(AS). Janus kinase 2 (JAK2) has been associated with AS. Urine-derived cells from an AS patient with JAK2 mutation were used to generate induced pluripotent stem cells (iPSCs) with five episomal iPSC reprogramming vectors (pCXLE-hOCT3/4-shp53-F, pCXLE-hSK, pCXLE-hUL, pCXLE-EGFP and pCXWB-EBNA1). The iPSCs were pluripotent and will be valuable for research on the role and mechanism of JAK2 in the pathogenesis of AS. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Hu J, Ren W, Qiu W, Lv J, Zhang C, Xu C, DU W, Wu M, Wang J, Quan R
Journal Stem cell research
Publication Date 2020 May;45:101788
PubMed 32388440
DOI 10.1016/j.scr.2020.101788

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