Non-integrating episomal vectors induced pluripotent stem cell line (SDPHi001-A) from a healthy female individual


Isolated peripheral blood mononuclear cells (PBMCs) from a healthy female were successfully transformed into induced pluripotent stem cells (iPSCs) by non-integrating episomal vectors containing OCT4, SOX2, c-MYC, KLF4, and BCL-XL. The iPSCs displayed a normal karyotype, expressed pluripotency markers and could differentiate into three germ layers in vitro. This iPSC line may be subsequently used for further researches. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Shao J, Shao C, Jin Y, Wang X, Fan H, Yang G
Journal Stem cell research
Publication Date 2021 Oct;56:102540
PubMed 34547706
DOI 10.1016/j.scr.2021.102540

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