Non-integrating episomal vectors induced pluripotent stem cell line (SDPHi001-A) from a healthy female individual
Summary
Isolated peripheral blood mononuclear cells (PBMCs) from a healthy female were successfully transformed into induced pluripotent stem cells (iPSCs) by non-integrating episomal vectors containing OCT4, SOX2, c-MYC, KLF4, and BCL-XL. The iPSCs displayed a normal karyotype, expressed pluripotency markers and could differentiate into three germ layers in vitro. This iPSC line may be subsequently used for further researches. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Shao J, Shao C, Jin Y, Wang X, Fan H, Yang G |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Oct;56:102540 |
| PubMed | 34547706 |
| DOI | 10.1016/j.scr.2021.102540 |