Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation
Summary
An optimal dose of hiPSC-NSC-EVs could significantly decrease the degeneration of human neurons induced by Aβ-42o. The results support further research into the effectiveness of hiPSC-NSC-EVs in AD, particularly their proficiency in preserving neurons and slowing disease progression. © 2025. The Author(s).
| Authors | Rao S, Madhu LN, Babu RS, Shankar G, Kotian S, Nagarajan A, Upadhya R, Narvekar E, Cai JJ, Shetty AK |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2025 Apr 18;16(1):191 |
| PubMed | 40251643 |
| PubMed Central | PMC12008877 |
| DOI | 10.1186/s13287-025-04324-3 |