Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation
Summary
An optimal dose of hiPSC-NSC-EVs could significantly decrease the degeneration of human neurons induced by Aβ-42o. The results support further research into the effectiveness of hiPSC-NSC-EVs in AD, particularly their proficiency in preserving neurons and slowing disease progression. © 2025. The Author(s).
Authors | Rao S, Madhu LN, Babu RS, Shankar G, Kotian S, Nagarajan A, Upadhya R, Narvekar E, Cai JJ, Shetty AK |
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Journal | Stem cell research & therapy |
Publication Date | 2025 Apr 18;16(1):191 |
PubMed | 40251643 |
PubMed Central | PMC12008877 |
DOI | 10.1186/s13287-025-04324-3 |