CS011iMEN1-n4

The cell line is not validated yet.

General

Cell Line

hPSCreg name CSMCi001-A
Cite as:
CSMCi001-A (RRID:CVCL_D0DM)
Alternative name(s)
CS011iMEN1-n4
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
CSMCi001-A-1
(CS011iMEN1-n4.Homo5, CS011MEN1-n4.HomoMut5)
Donor diseases:
multiple endocrine neoplasia type 1
CSMCi001-A-2
(2. CS011MEN1-n4.Corrected1)
Donor diseases:
multiple endocrine neoplasia type 1
Last update 15th February 2023
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Provider

Generator Cedars Sinai Medical Center, (CSMC)

External Databases

BioSamples SAMEA112648426
Cellosaurus CVCL_D0DM
Wikidata Q123030972

General Information

Publications
* Is the cell line readily obtainable for third parties?
No
Subclones

Donor Information

General Donor Information

Sex female

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation and affected.
Synonyms
  • multiple endocrine adenomatosis
  • MEA type 1
  • MEA type I
  • MEN1
  • MEN1 multiple endocrine neoplasia
  • MEN1 syndrome
  • Wermer syndrome
  • Wermer's syndrome
  • men 1
  • men type 1
  • men type I
  • multiple endocrine adenomatosis type 1
  • multiple endocrine adenomatosis type I
  • multiple endocrine adenomatosis, type I
  • multiple endocrine neoplasia 1
  • multiple endocrine neoplasia caused by mutation in MEN1
  • multiple endocrine neoplasia type 1
  • multiple endocrine neoplasia type 1 syndrome
  • multiple endocrine neoplasia type I
  • multiple endocrine neoplasia, type I
  • MEA 1
  • MEN1 somatic mutations
  • endocrine adenomatosis multiple
  • endocrine adenomatosis, multiple
  • multiple endocrine neoplasia, type 1
show more synonyms

External Databases (Donor)

BioSamples SAMEA112648427

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Please provide contact information of the holder of the original Donor Information Sheet. Cedars Sinai Medical Center
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Please provide the contact information Cedars Sinai Medical Center
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? No information
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Cedars Sinai Medical Center IRB
Approval number Cedars Sinai Medical Center IRB Pro00028515/ CR00014232
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes.
Synonyms
  • PERIPHERAL BLOOD MONONUCLEAR CELL
  • Peripheral Blood Mononuclear Cell
  • PBMC

Reprogramming method

Vector type Non-integrating
Vector Episomal

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium mTeSR™ Plus

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
NANOG
Yes
SOX2
Yes
Score:
Marker Present Absent
mCpG
OCT4
Self-renewal
Positive
Endoderm
Negative
Mesoderm
Negative
Ectoderm score
Negative
Differentiation Potency

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46XX

Other Genotyping (Cell Line)