Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ


The human iPSC cell line ZJUCHi001-A was established from renal epithelial cells present in urine (urinary cells) harvested from a 2-year-old Charcot-Marie-Tooth disease type 1B (CMT1B) patient carrying point mutation in MPZ (c.292C>T). Urinary cells were reprogrammed by retrovirus vectors containing reprogramming factors: OCT4, SOX2, KLF4 and c-MYC. The pluripotency, capacity of differentiation into 3 germ layers, silence of reprogramming factors and normal karyotype for this cell line were all confirmed in this study. Copyright © 2019. Published by Elsevier B.V.

Authors Xu J, Wang Y, He J, Xia W, Zou Y, Ruan W, Lou Q, Li Y, Li H, Chen W
Journal Stem cell research
Publication Date 2019 Mar;35:101407
PubMed 30785048
DOI 10.1016/j.scr.2019.101407

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