Lipopolysaccharide induces retention of E-cadherin in the endoplasmic reticulum and promotes hybrid epithelial-to-mesenchymal transition of human embryonic stem cells-derived expandable lung epithelial cells
Summary
Human embryonic stem cell-derived ELEPs provide a biologically relevant, non-cancerous lung cell model to investigate molecular responses to inflammatory stimuli and address epithelial plasticity. This approach offers novel insights into the fine molecular processes underlying lung injury and repair. © 2025. The Author(s).
| Authors | Portakal T, Havlíček V, Herůdková J, Pelková V, Gruntová T, Çakmakci RC, Kotasová H, Hampl A, Vaňhara P |
|---|---|
| Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.] |
| Publication Date | 2025 May 24;74(1):82 |
| PubMed | 40413286 |
| PubMed Central | PMC12103375 |
| DOI | 10.1007/s00011-025-02041-4 |