Familial combined hyperlipidemia is a polygenic trait
: Recent progress in genomics has shown that most if not all of the genetic susceptibility to FCH is polygenic in nature. Future research should include larger cohort studies, with wider ancestral diversity, ancestry-specific polygenic scores, and investigation of epigenetic and lifestyle factors to help further elucidate the causative agents at play in cases where the genetic etiology remains to be defined. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
|Authors||Gill PK, Hegele RA|
|Journal||Current opinion in lipidology|
|Publication Date||2022 Apr 1;33(2):126-132|