Characterization of a human induced Pluripotent Stem (iPS) cell line (INCABRi002-A) derived from a primary myelofibrosis patient harboring the 5-bp insertion in CALR and the p.W146X mutation in TP53
Summary
Primary myelofibrosis (PMF) is a hematological malignancy characterized by activation of the JAK/STAT pathway and risk of leukemic transformation. In this study, we generated an induced Pluripotent Stem (iPS) cell line derived from a 65-year old male PMF patient carrying the 5-pb insertion in the CALR gene (CALRins5) and the c.437 G > A mutation in the TP53 gene (p.W146X). The newly derived PMF3.17 iPS cell line harbors the original mutations and was characterized as bona fide iPS. Resource table. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Gomez Limia CE, Devalle S, Reis M, Sochacki J, Madeiro da Costa R, D'Andrea M, Padilha T, Zalcberg IR, Solza C, Daumas A, Rehen S, Bonamino MH, Monte-Mór B |
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| Journal | Stem cell research |
| Publication Date | 2018 Dec;33:130-134 |
| PubMed | 30343103 |
| DOI | 10.1016/j.scr.2018.09.012 |