Characterization of a human induced Pluripotent Stem (iPS) cell line (INCABRi002-A) derived from a primary myelofibrosis patient harboring the 5-bp insertion in CALR and the p.W146X mutation in TP53


Primary myelofibrosis (PMF) is a hematological malignancy characterized by activation of the JAK/STAT pathway and risk of leukemic transformation. In this study, we generated an induced Pluripotent Stem (iPS) cell line derived from a 65-year old male PMF patient carrying the 5-pb insertion in the CALR gene (CALRins5) and the c.437 G > A mutation in the TP53 gene (p.W146X). The newly derived PMF3.17 iPS cell line harbors the original mutations and was characterized as bona fide iPS. Resource table. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Gomez Limia CE, Devalle S, Reis M, Sochacki J, Madeiro da Costa R, D'Andrea M, Padilha T, Zalcberg IR, Solza C, Daumas A, Rehen S, Bonamino MH, Monte-Mór B
Journal Stem cell research
Publication Date 2018 Dec;33:130-134
PubMed 30343103
DOI 10.1016/j.scr.2018.09.012

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