Generation of three human induced pluripotent stem cell (hiPSC) lines derived from one Gaucher disease patient with Parkinson's disease and two unrelated Parkinson's disease patients with GBA mutations
Summary
We describe the generation and characterization of hiPSC lines of one type 1-Gaucher disease patient with Parkinson's disease and two unrelated Parkinson's disease patients heterozygous for GBA mutations. Human iPSCs were derived from lymphocytes reprogrammed with Sendai virus carrying the reprogramming factors OCT3/4, SOX2, KLF4 and MYC. The hiPSC lines were characterized according to established criteria, and retained the original GBA mutations found in the respective patients. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Tofoli FA, Chien HF, Barbosa ER, Pereira LV |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2019 Aug;39:101519 |
| PubMed | 31401455 |
| DOI | 10.1016/j.scr.2019.101519 |