Generation of a human induced pluripotent stem cell line PUMCHi019-A from a dominant optic atrophy patient with an OPA1 mutation


Dominant optic atrophy (DOA) is one of the most common type of hereditary optic atrophy. Here, we describe the generation and characterization of a human induced pluripotent stem cell (hiPSC) line of DOA patient with an OPA1 mutation. The reprogramming of this iPSC line was performed from peripheral blood mononuclear cells (PBMCs) using the non-integrative Sendai virus. The established hiPSC line retained the disease-associated mutation and showed normal karyotype, pluripotency, and differentiation capacity. Copyright © 2022. Published by Elsevier B.V.

Authors Sun Z, Wu S, Zhu T, Wei X, Han X, Zou X, Sui R
Journal Stem cell research
Publication Date 2022 Apr;60:102705
PubMed 35152176
DOI 10.1016/j.scr.2022.102705

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