Generation of integration-free human iPSC line LCPHi001-A from a Parkinson's disease patient carrying the RecNciI mutation in GBA gene


Parkinson's disease (PD) is a neurodegenerative disease caused by environmental and genetic factors. The identified PD genes include SNCA, LRRK2, Parkin, DJ-1, PINK1, and ATP13A2. Mutations in the glucocerebrosidase (GBA) gene were reported to be associated with PD in different ethnic populations. Here we generated a novel induced pluripotent stem cell (iPSC) line LCPHi001-A from a PD patient carrying RecNciI mutation (c.1448 T > C, c.1483G > C, and c.1497G > C) in GBA by non-integrative episomal plasmids. The LCPHi001-A line expressed pluripotency markers, displayed differentiation capacity to three germ layers in vivo, and had the normal karyotype. Copyright © 2021. Published by Elsevier B.V.

Authors Lu X, Song N, Wang W, Liu Y, Song H, Xu L, Wang Y, Wei C, Chen J, Yang X, Han F
Journal Stem cell research
Publication Date 2021 Oct;56:102514
PubMed 34464855
DOI 10.1016/j.scr.2021.102514

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