Establishment of induced pluripotent stem cells from schizophrenia discordant fraternal twins


Schizophrenia (SCZ) is one of the major psychiatric disorders. The genetic factor is certainly influential in the onset of the disease but is not decisive. There is no identified molecular/cellular marker of the disease, and the pathomechanism is still unknown. In this study, we generated human induced pluripotent stem cells (iPSCs) derived from SCZ-discordant fraternal twins, and they could contribute to elucidation of the pathomechanism of SCZ. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Yada Y, Suga M, Shibukawa R, Sagara Y, Okanishi Y, Enami T, Tsukita K, Kondo T, Imamura K, Sugihara G, Murai T, Inoue H
Journal Stem cell research
Publication Date 2021 Aug;55:102504
PubMed 34419750
DOI 10.1016/j.scr.2021.102504

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