Generation of two iPSC clones (MHHi021-A and MHHi021-B) from a patient with hypertrophic cardiomyopathy with p.Arg723Gly mutation in the MYH7 gene


Hypertrophic cardiomyopathy (HCM) is the most common form of genetic heart disease and is characterized by abnormal thickening of the left ventricular wall and interventricular septum. Here we describe the generation of two induced pluripotent stem cell (iPSC) clones from a HCM patient, heterozygous for the p.Arg723Gly (c.2169C > G) mutation in the MYH7 gene. The generated iPSC clones may provide a useful resource for disease modelling to study the mechanisms underlying HCM pathogenesis in iPSC derived progenies, in particular cardiomyocytes. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Merkert S, Wunderlich S, Beier J, Franke A, Schwanke K, Göhring G, Kraft T, Francino A, Zweigerdt R, Martin U
Journal Stem cell research
Publication Date 2021 Apr;52:102208
PubMed 33578365
DOI 10.1016/j.scr.2021.102208

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