Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease


Skin fibroblasts were collected from a 44-year-old patient with sporadic case of Parkinson's disease (PD). The non-integrating Sendai virus vector encoding OCT3/4, SOX2, c-MYC and KLF4 was used to reprogram fibroblasts into induced pluripotent stem cells (iPSCs). Generated iPSCs had normal karyotypes, expressed common stem cell markers, and were capable of differentiating into all three germ layers. Generated line could be used for PD modeling to understand the mechanisms that influence the disorder. Copyright © 2018. Published by Elsevier B.V.

Authors Savchenko E, Marote A, Russ K, Collin A, Goldwurm S, Roybon L, Pomeshchik Y
Journal Stem cell research
Publication Date 2018 Mar;27:78-81
PubMed 29334629
DOI 10.1016/j.scr.2018.01.002

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