Increased Ca(2+) signaling in NRXN1α(+/-) neurons derived from ASD induced pluripotent stem cells
Summary
This is the first report to show that human NRXN1α+/- neurons derived from ASD patients' iPSCs present novel phenotypes of upregulated VGCCs and increased Ca2+ transients, which may facilitate the development of drug screening assays for the treatment of ASD. © The Author(s). 2019.
| Authors | Avazzadeh S, McDonagh K, Reilly J, Wang Y, Boomkamp SD, McInerney V, Krawczyk J, Fitzgerald J, Feerick N, O'Sullivan M, Jalali A, Forman EB, Lynch SA, Ennis S, Cosemans N, Peeters H, Dockery P, O'Brien T, Quinlan LR, Gallagher L, Shen S |
|---|---|
| Journal | Molecular autism |
| Publication Date | 2019;10:52 |
| PubMed | 31893021 |
| PubMed Central | PMC6937972 |
| DOI | 10.1186/s13229-019-0303-3 |