Establishment of an iPSC line (JSPHi001-A) from a patient with familial dilated cardiomyopathy and atrial fibrillation caused by LMNA missense mutation (c.1003C > T)

Summary

Peripheral blood mononuclear cells (PBMCs) were harvested and reprogramed to induced pluripotent stem cells (iPSCs) from a 46-year-old male patient with familial dilated cardiomyopathy and atrial fibrillation via a non-integrating system. A missense mutation in the LMNA gene (c.1003C > T) was identified by whole-exome sequencing and verified by Sanger sequencing. The pluripotency, differentiation potential, and karyotype of this cell line were also tested. This model is helpful to study the phenotype, mechanism, and therapy for laminopathy. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Zhang Y, Zhu Y, Lin Y, Liu H, Chen H, Ju W, Cui C, Chen M
Journal Stem cell research
Publication Date 2021 Apr 16;53:102349
PubMed 33887581
DOI 10.1016/j.scr.2021.102349

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