Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations
Summary
We generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of breast cancer patients carrying germline ATM mutations, a gene associated with a 7% prevalence in breast cancer. These iPSC lines displayed typical morphology, expressed pluripotency markers, maintained a stable karyotype, and retained the ability to differentiate into the three germ layers. These patient-specific iPSC lines hold great potential for mechanistic investigations and the development of drug screening strategies aimed at addressing ATM-related cancer. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Zhang M, Venkateshappa R, Li A, Fowler MB, Telli ML, Wu JC |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Dec;73:103246 |
| PubMed | 37951143 |
| PubMed Central | PMC10789563 |
| DOI | 10.1016/j.scr.2023.103246 |