Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line (CSUXHi005-A) from human urine epithelial cells

Summary

Urine epithelial cells were harvested from a 32-year old female patient with spinocerebellar ataxia type 3 (SCA3) and reprogrammed into induced pluripotent stem cells (iPSCs) by non-integration system. The SCA3 derived iPSCs line, CSUXHi005-A, maintained 76 CAG expansions in the ATXN3 gene, was characterized by the expression of pluripotency markers and normal karyotype. The newly generated iPSCs retain the ability to differentiate into three germ layers by teratoma test, which provide an ideal tool for disease modeling, drug screening, and cellular therapy. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors He L, Han X, Zhao H, Li S, Chen Z, Wang C, Wang S, Peng L, Deng W, Li Z, Tang B, Jiang H
Journal Stem cell research
Publication Date 2021 Mar 17;53:102289
PubMed 33761381
DOI 10.1016/j.scr.2021.102289

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