Generation of induced pluripotent stem cell line(ZZUi006-A)from a patient with myotonic dystrophy type 1


Myotonic dystrophy type 1 (DM1) is a dominantly inherited neurodegenerative disease caused by a CTG repeat expansion close to the DMPK gene. The fibroblasts from a patient with DM1 were successfully converted to induced pluripotent stem cells (iPSCs), designated ZZUi006-A, by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, L-MYC. The ZZUi006-A cell line may provide a robust platform for further study of DM1 pathogenesis as well as drug testing and gene therapy research. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wang Y, Wang Z, Sun H, Shi C, Yang J, Liu Y, Liu H, Zhang S, Zhang L, Xu Y, Zhang J
Journal Stem cell research
Publication Date 2018 Oct;32:61-64
PubMed 30216892
DOI 10.1016/j.scr.2018.08.013

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