Generation of induced pluripotent stem cell line(ZZUi006-A)from a patient with myotonic dystrophy type 1
Summary
Myotonic dystrophy type 1 (DM1) is a dominantly inherited neurodegenerative disease caused by a CTG repeat expansion close to the DMPK gene. The fibroblasts from a patient with DM1 were successfully converted to induced pluripotent stem cells (iPSCs), designated ZZUi006-A, by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, L-MYC. The ZZUi006-A cell line may provide a robust platform for further study of DM1 pathogenesis as well as drug testing and gene therapy research. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Wang Y, Wang Z, Sun H, Shi C, Yang J, Liu Y, Liu H, Zhang S, Zhang L, Xu Y, Zhang J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2018 Oct;32:61-64 |
| PubMed | 30216892 |
| DOI | 10.1016/j.scr.2018.08.013 |