Microglial amyloid beta clearance is driven by PIEZO1 channels
Summary
These results indicate that the compromised function of microglia in AD could be improved by controlled activation of PIEZO1 channels resulting in alleviated Aβ burden. Pharmacological regulation of these mechanoreceptors in microglia could represent a novel therapeutic paradigm for AD. © 2022. The Author(s).
| Authors | Jäntti H, Sitnikova V, Ishchenko Y, Shakirzyanova A, Giudice L, Ugidos IF, Gómez-Budia M, Korvenlaita N, Ohtonen S, Belaya I, Fazaludeen F, Mikhailov N, Gotkiewicz M, Ketola K, Lehtonen Š, Koistinaho J, Kanninen KM, Hernández D, Pébay A, Giugno R, Korhonen P, Giniatullin R, Malm T |
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| Journal | Journal of neuroinflammation |
| Publication Date | 2022 Jun 15;19(1):147 |
| PubMed | 35706029 |
| PubMed Central | PMC9199162 |
| DOI | 10.1186/s12974-022-02486-y |