Generation of two iPSC lines (FAMRCi004-A and FAMRCi004-B) from patient with familial progressive cardiac conduction disorder carrying genetic variant DSP p.His1684Arg


Human iPSC cell lines (FAMRCi004-A and FAMRCi004-B) were generated from patient with progressive cardiac conduction disease and sick sinus syndrome carrying DSP p.His1684Arg genetic variant. Patient-specific adipose tissue-derived mesenchymal multipotent stromal cells were reprogrammed using non-integrative Sendai viruses. Established iPSC lines showed normal karyotype, expressed pluripotent markers and were able to differentiate toward three germ layers in vitro. The reported iPSC lines could be useful tool for in vitro modeling of progressive cardiac conduction disease associated with mutations in desmosomal genes. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Khudiakov A, Perepelina K, Klauzen P, Zlotina A, Gusev K, Kaznacheyeva E, Malashicheva A, Kostareva A
Journal Stem cell research
Publication Date 2020 Mar;43:101720
PubMed 32062131
DOI 10.1016/j.scr.2020.101720

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