iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion
Summary
IR-iPSCs generated from offspring of diabetic patients confirm that oxidative stress and increased lactate secretion, associated with IR, are inherited in this population, and may place them at a high risk of T2D. Overall, our IR-iPSC model can be employed for T2D modeling and drug screening studies that target genetic perturbations associated with IR in individuals with a high risk for T2D. © 2022. The Author(s).
| Authors | Memon B, Elsayed AK, Bettahi I, Suleiman N, Younis I, Wehedy E, Abou-Samra AB, Abdelalim EM |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2022 Aug 20;13(1):428 |
| PubMed | 35987697 |
| PubMed Central | PMC9392338 |
| DOI | 10.1186/s13287-022-03123-4 |