Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes


Collectively, we developed a fast, easy, and economical method to induce iPSC-CMs maturation via PPAR/PGC-1α activation. Treatment with AA or GW led to increased metabolic, structural, functional, and electrophysiological maturation, evaluated using a multiparametric quality assessment. © 2022. The Author(s).

Authors Chirico N, Kessler EL, Maas RGC, Fang J, Qin J, Dokter I, Daniels M, Šarić T, Neef K, Buikema JW, Lei Z, Doevendans PA, Sluijter JPG, van Mil A
Journal Stem cell research & therapy
Publication Date 2022 Dec 27;13(1):531
PubMed 36575473
PubMed Central PMC9795728
DOI 10.1186/s13287-022-03209-z

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