Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes
Summary
Collectively, we developed a fast, easy, and economical method to induce iPSC-CMs maturation via PPAR/PGC-1α activation. Treatment with AA or GW led to increased metabolic, structural, functional, and electrophysiological maturation, evaluated using a multiparametric quality assessment. © 2022. The Author(s).
| Authors | Chirico N, Kessler EL, Maas RGC, Fang J, Qin J, Dokter I, Daniels M, Šarić T, Neef K, Buikema JW, Lei Z, Doevendans PA, Sluijter JPG, van Mil A |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2022 Dec 27;13(1):531 |
| PubMed | 36575473 |
| PubMed Central | PMC9795728 |
| DOI | 10.1186/s13287-022-03209-z |