Generation of a Human iPSC line (SDQLCHi021-A) from a patient with methylmalonic acidemia cblC type carrying compound heterozygous mutations in MMAHC gene
Summary
Methylmalonic acidemia and homocystinuria, cblC type is a rare autosomal recessive inheritance disease. Its clinical phenotype involves multiple systems with varying degrees of severity. The disease is caused by the mutations in the MMACHC gene located on chromosome 1p34.1. Here we report the generation of an iPSC line from the PBMCs of a patient with compound heterozygous mutations in the MMACHC gene. This new iPSC line will allow a better understanding of the MMA disease. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Guan J, Li Z, Zhang H, Yang X, Ma Y, Li Y, Dong R, Gai Z, Liu Y |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Mar;43:101709 |
| PubMed | 32058304 |
| DOI | 10.1016/j.scr.2020.101709 |