COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab
Summary
Serum derived from COVID19 patients exerts acute cardio-depressant and chronic pro-arrhythmogenic effects in rat and iPS-derived cardiomyocytes. Canakinumab had no beneficial effect on cellular Ca2+ signaling during excitation-contraction coupling. The presented method utilizing iPS-CM and in-vitro Ca2+ imaging might serve as a novel tool for precision medicine. It allows to investigate cytokine related cardiac dysfunction and pharmacological approaches useful therein.
| Authors | Dimai S, Semmler L, Prabhu A, Stachelscheid H, Huettemeister J, Klaucke SC, Lacour P, Blaschke F, Kruse J, Parwani A, Boldt LH, Bullinger L, Pieske BM, Heinzel FR, Hohendanner F |
|---|---|
| Journal | PloS one |
| Publication Date | 2021;16(8):e0255976 |
| PubMed | 34411149 |
| PubMed Central | PMC8376065 |
| DOI | 10.1371/journal.pone.0255976 |