Generation of a human iPSC line (CIBi013-A) from a patient with young-onset Parkinson's disease carrying a novel homozygous PARK7 (DJ-1) mutation
Mutations in PARK7 and the resulting alterations in its production protein (DJ-1) are tightly associated with Parkinson's disease. We generated a human induced pluripotent stem cell (iPSC) line (CIBi013-A) from a patient with young-onset Parkinson's disease (YOPD) who carried a novel homozygous PARK7 (DJ-1) mutation (chr1:8037723, c.334C>G). The generated iPSCs will be used for investigating phenotype and underlying molecular mechanisms in patient-derived cells. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
|Authors||Li L, Si X, Lei M, Yang J, Ruan J, Liu H, Huang F, Jin X, Xie K, Yang H, Lei X, Liu Y|
|Journal||Stem cell research|
|Publication Date||2022 Nov 24;66:102983|