Generation of a human iPSC line (CIBi013-A) from a patient with young-onset Parkinson's disease carrying a novel homozygous PARK7 (DJ-1) mutation

Summary

Mutations in PARK7 and the resulting alterations in its production protein (DJ-1) are tightly associated with Parkinson's disease. We generated a human induced pluripotent stem cell (iPSC) line (CIBi013-A) from a patient with young-onset Parkinson's disease (YOPD) who carried a novel homozygous PARK7 (DJ-1) mutation (chr1:8037723, c.334C>G). The generated iPSCs will be used for investigating phenotype and underlying molecular mechanisms in patient-derived cells. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Li L, Si X, Lei M, Yang J, Ruan J, Liu H, Huang F, Jin X, Xie K, Yang H, Lei X, Liu Y
Journal Stem cell research
Publication Date 2023 Feb;66:102983
PubMed 36469984
DOI 10.1016/j.scr.2022.102983

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