Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy
Summary
Inherited dilated cardiomyopathy (iDCM) is a disease of the heart muscle, characterized by left ventricle enlargement, systolic dysfunction and arrhythmias. iDCM represents a common cause of heart failure and the most frequent cause of heart transplantation. Among the causative genes, TTN, encoding the sarcomeric protein Titin, represents the most prevalent (about 25 % of cases). The heterogeneous clinical manifestations and variable response to therapy represent a major challenge in patients' clinical management. To deepen the knowledge of this disease, we generated and fully characterized induced Pluripotent Stem Cell lines from 4 iDCM patients carrying 4 different truncating variants of TTN gene. Copyright © 2025. Published by Elsevier B.V.
| Authors | Thairi C, Artioli R, Paulis M, Galli C, Cotič S, Paldino A, Marino I, Sinagra G, Collesi C, Dal Ferro M, Di Pasquale E |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Apr 20;86:103719 |
| PubMed | 40286602 |
| DOI | 10.1016/j.scr.2025.103719 |