Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation
Summary
Genetic polymorphism of apolipoprotein E (APOE) confers differential susceptibility to Alzheimer's disease (AD), and APOE ɛ4 variants is the most powerful risk factor for this disease. Here, we report the generation of a human induced pluripotent stem cell (iPSC) line carrying the APOE ɛ4/ɛ4 genotype from peripheral blood mononuclear cells (PBMCs) isolated from a male with a family history of AD utilizing non-integrative Sendai virus vector. The iPSC maintains their original genotype, highly express endogenous pluripotency markers, displays a normal karyotype, and retains the ability to differentiate into cells representative of the three germ layers. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Wang P, Sun W, Gong J, Han X, Xu C, Chen Y, Yang Y, Luan H, Li S, Li R, Wen B, Lv S, Chen R, Guo J, Wei C |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Jun;77:103398 |
| PubMed | 38552354 |
| DOI | 10.1016/j.scr.2024.103398 |