Generation of a hiPSC line ZZUNEUi017-A from a patient with dilated cardiomyopathy caused by mutation in TTN
Summary
Dilated cardiomyopathy (DCM) is the commonest type of cardiomyopathy. In this study, peripheral blood mononuclear cells (PBMCs) were isolated from a DCM patient with the p. Glu12513fs(c.37537delG) mutation in TTN and were reprogrammed to human induced pluripotent stem cells (iPSCs). The ZZUNEUi017-A iPSC line expressed pluripotency markers, exhibiting a normal male karyotype (46, XY) and demonstrating differentiation potential into three germ layers in vitro. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Huang S, Fu W, Guo G, Tiana X, Zhao X, Dong J, Li X, Yang H |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Apr;52:102248 |
| PubMed | 33610015 |
| DOI | 10.1016/j.scr.2021.102248 |