Generation of a hiPSC line ZZUNEUi017-A from a patient with dilated cardiomyopathy caused by mutation in TTN

Summary

Dilated cardiomyopathy (DCM) is the commonest type of cardiomyopathy. In this study, peripheral blood mononuclear cells (PBMCs) were isolated from a DCM patient with the p. Glu12513fs(c.37537delG) mutation in TTN and were reprogrammed to human induced pluripotent stem cells (iPSCs). The ZZUNEUi017-A iPSC line expressed pluripotency markers, exhibiting a normal male karyotype (46, XY) and demonstrating differentiation potential into three germ layers in vitro. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Huang S, Fu W, Guo G, Tiana X, Zhao X, Dong J, Li X, Yang H
Journal Stem cell research
Publication Date 2021 Feb 15;52:102248
PubMed 33610015
DOI 10.1016/j.scr.2021.102248

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