Generation of nine iPSC lines (HNMUi002-A, HNMUi003-A, HNMUi004-A, HNMUi005-A, HNMUi006-A, HNMUi007-A, HNMUi008-A, HNMUi009-A, HNMUi010-A) from three Chinese families with thalassemia
Summary
Thalassemia is a group of single-gene recessive inherited hemoglobin disorders caused by a mutation or deletion of one or more globin genes, which results in abnormal globin chain synthesis and hemoglobin formation. In this study, human iPSC lines HNMUi002-A, HNMUi003-A, HNMUi004-A, HNMUi005-A, HNMUi006-A, HNMUi007-A, HNMUi008-A, HNMUi009-A, HNMUi010-A were generated from the amniotic fluid cells or urine-derived cells isolated from 9 patients with thalassemia. The iPSC lines exhibited the normal karyotype, expressed pluripotency markers, and carried α- or β- globin gene mutations. These pluripotent stem cell lines will serve as useful tools for studying pathophysiological mechanism of thalassemia. Copyright © 2020. Published by Elsevier B.V.
| Authors | Long P, Wang Z, Yang H, Liu Z, Wu B, Zhong G, Chen J, Sun C, Wang F, Zhou Y, Sun F, Li Q, Ma Y |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Dec;49:102014 |
| PubMed | 33039806 |
| DOI | 10.1016/j.scr.2020.102014 |