Integration-free induced pluripotent stem cell line derived from a 62-years-old male donor with APOE-epsilon4/epsilon4 alleles


The ε4 allele of the Apolipoprotein E gene (APOE4) continues to be the strongest genetic risk factor associated with sporadic Alzheimer's disease since its discovery compared to the most common ε3 allele. Nevertheless, there is a lack of APOE4-mutant human neuronal models in vitroor in vivo. Hence, we presented an iPSC line of an APOE-ε4/ε4 alleles carrier, a male donor suffering from Alzheimer's disease combined with cerebral infarction. The established iPSC line showed standard characteristics of pluripotency. Collectively, the present study provides a useful resource to reveal the phenotype and explore the mechanism of APOE4 related Alzheimer's disease. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Guo R, Liu X, Zhang J, Ma X, Gou D, Ma Z, Wang L, Ma J, Cui H
Journal Stem cell research
Publication Date 2022 May;61:102746
PubMed 35305470
DOI 10.1016/j.scr.2022.102746

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