Generation of induced pluripotent stem cell line (XWHNi002-A) from a female with APP gene mutation


The β-amyloid precursor protein (APP) is a crucial pathogenic gene linked to Alzheimer's disease (AD). A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) isolated from a female with APP gene mutation utilizing non-integrative Sendai virus. The iPSC line exhibits high expression of pluripotency markers, retains the APP mutation, displays a normal karyotype, and has the ability to differentiate into normal teratoma tissue. This iPSC line represents a valuable cell model for investigating the pathological mechanisms and therapeutic strategies of AD. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Sun W, Wang P, Gong J, Chen Y, Yang Y, Luan H, Li S, Li R, Wei C
Journal Stem cell research
Publication Date 2023 Sep;71:103149
PubMed 37356183
DOI 10.1016/j.scr.2023.103149

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