Generation of induced pluripotent stem cell line (XWHNi002-A) from a female with APP gene mutation
Summary
The β-amyloid precursor protein (APP) is a crucial pathogenic gene linked to Alzheimer's disease (AD). A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) isolated from a female with APP gene mutation utilizing non-integrative Sendai virus. The iPSC line exhibits high expression of pluripotency markers, retains the APP mutation, displays a normal karyotype, and has the ability to differentiate into normal teratoma tissue. This iPSC line represents a valuable cell model for investigating the pathological mechanisms and therapeutic strategies of AD. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Sun W, Wang P, Gong J, Chen Y, Yang Y, Luan H, Li S, Li R, Wei C |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Sep;71:103149 |
| PubMed | 37356183 |
| DOI | 10.1016/j.scr.2023.103149 |