Gain of 20q11.21 in human pluripotent stem cells enhances differentiation to retinal pigment epithelium
Summary
We demonstrated that gain of 20q11.21 enhances the speed and yield of RPE differentiation without compromising the phenotype of the derivatives. Finally, we discovered that 20q11.21-localised BCL-XL is important for RPE differentiation with potential non-canonical roles in retinal biology. © 2025. The Author(s).
| Authors | Vitillo L, Anjum F, Hewitt Z, Laing O, Ababneh NA, Baker D, Barbaric I, Coffey PJ |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2025 Feb 21;16(1):82 |
| PubMed | 39985055 |
| PubMed Central | PMC11846190 |
| DOI | 10.1186/s13287-025-04196-7 |