Construction of induced pluripotent stem cell line (ZZUi031-A) of a healthy young Chinese Han male


We have successively constructed several induced pluripotent stem cell (iPSC) lines of middle-aged and elderly male, but cell samples from young donors are still scarce. In this project, we recruited a healthy 29-year-old Chinese Han male, obtained his skin fibroblasts and successfully established iPSC line using non-integrated reprogramming technology. The iPSC line showed normal karyotype, expressed pluripotency markers and differentiated into three germ layers in vivo. The cell line will serve as an available control in the research of pathological mechanisms of early-onset neurological diseases. Copyright © 2021. Published by Elsevier B.V.

Authors Li S, Wang Y, Sun H, Wang Z, Zhang Q, Wang Y, Yang J, Shi C, Yuan Y, Wang H, Fan L, Li Z, Xu Y
Journal Stem cell research
Publication Date 2021 Nov 27;57:102608
PubMed 34856467
DOI 10.1016/j.scr.2021.102608

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