Generation of an induced pluripotent stem cell line ZZUNEUi019-A from a five-year-old Chinese girl with Susceptibility to idiopathic generalized epilepsy-15
Summary
Susceptibility to idiopathic generalized epilepsy-15 (EIG15) is an autosomal dominant seizure disorder characterized by onset of variable types of seizures in the first decade, caused by heterozygous mutations in the RORB gene encoding the retinoid-related orphan receptor β. We established an induced pluripotent stem cell (iPSC) line from PBMCs collected from a five-year-old female patient with EIG15, via reprogramming with OCT3/4, SOX2, KLF4, and c-MYC. Upon careful examination, the iPSCs stably expressed pluripotent genes, maintained a normal karyotype, and had full potential for three-germ layer differentiation. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Dong W, Shi D, Zhang L, Huang M, Luo Q |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Mar;51:102177 |
| PubMed | 33540281 |
| DOI | 10.1016/j.scr.2021.102177 |