Generation of an induced pluripotent stem cell line ZZUNEUi019-A from a five-year-old Chinese girl with Susceptibility to idiopathic generalized epilepsy-15

Summary

Susceptibility to idiopathic generalized epilepsy-15 (EIG15) is an autosomal dominant seizure disorder characterized by onset of variable types of seizures in the first decade, caused by heterozygous mutations in the RORB gene encoding the retinoid-related orphan receptor β. We established an induced pluripotent stem cell (iPSC) line from PBMCs collected from a five-year-old female patient with EIG15, via reprogramming with OCT3/4, SOX2, KLF4, and c-MYC. Upon careful examination, the iPSCs stably expressed pluripotent genes, maintained a normal karyotype, and had full potential for three-germ layer differentiation. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Dong W, Shi D, Zhang L, Huang M, Luo Q
Journal Stem cell research
Publication Date 2021 Jan 15;51:102177
PubMed 33540281
DOI 10.1016/j.scr.2021.102177

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