Inhibition of ceramide synthesis improves the outcome of ischemia/reperfusion injury in cardiomyocytes derived from human induced pluripotent stem cell
Summary
Results from both in vitro and in vivo experiments show that ceramides have a significant role in either mediating or inducing damage to CMs. Additionally, in vitro findings show that ceramide reduction improves the outcome of IR injury by lowering intracellular Ca2+ [Ca2+]i concentration and improves mitochondrial function changes during IR. © 2025. The Author(s).
| Authors | Haxhikadrija P, Wu JMF, Hübner S, Grün K, Kretzschmar T, Müller T, Gräler MH, Backsch C, Weise A, Klein E, Schulze PC, Bekhite MM |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2025 Apr 18;16(1):190 |
| PubMed | 40251632 |
| PubMed Central | PMC12008854 |
| DOI | 10.1186/s13287-025-04340-3 |