Derivation of iPSC lines from two patients with familial Alzheimer's disease from India
Summary
The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD. Copyright © 2018. Published by Elsevier B.V.
| Authors | Najar AH, Sneha KM, Ashok A, Babu S, Subramaniam AG, Kannan R, Viswanath B, Purushottam M, Varghese M, Parvez S, Panicker MM, Mukherjee O, Jain S |
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| Journal | Stem cell research |
| Publication Date | 2019 Jan;34:101370 |
| PubMed | 30605839 |
| DOI | 10.1016/j.scr.2018.101370 |