Reprogramming of human olfactory neurosphere-derived cells from olfactory mucosal biopsies of a control cohort


Human olfactory neurosphere-derived (ONS) cells are derived from the olfactory mucosa and display some progenitor- and neuronal cell-like properties, making them useful models of neurological disorders. However, they lack several important characteristics of true neurons, which can be overcome using induced pluripotent stem cell (iPSC) -derived neurons. Here we describe, for the first time, the generation and validation of an iPSC line from an olfactory biopsy from a control cohort member. This data lays the groundwork for future reprogramming of ONS cells, which can be used to generate neuronal models and compliment current ONS cell-based investigations into numerous neurological disorders. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Leeson HC, Hunter Z, Chaggar HK, Mackay-Sim A, Wolvetang EJ
Journal Stem cell research
Publication Date 2021 Oct;56:102527
PubMed 34507143
DOI 10.1016/j.scr.2021.102527

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