Establishment of an induced pluripotent stem cell line (ICGi026-A) from peripheral blood mononuclear cells of a patient with fragile X syndrome


Expansion over 200 CGG repeats in FMR1 gene causes inherited intellectual disability or autism spectrum disorder named as fragile X syndrome. Despite the known cause fragile X syndrome pathogenesis has not been specified yet. The ICGi026-A iPSCs line was obtained by the reprogramming of the peripheral blood mononuclear cells from a 9-year-old boy with fragile X syndrome. The ICGi026-A iPSCs expressed pluripotency markers, had a normal male karyotype (46, XY) and had the capacity to in vivo differentiate into the cells of three germ layers. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Gridina MM, Orlova PA, Minina JM, Shitik EM, Lemskaya NA, Grishchenko IV, Dolskiy AA, Shorina AR, Maksimova YV, Yudkin DV, Serov OL
Journal Stem cell research
Publication Date 2020 Dec;49:102070
PubMed 33189043
DOI 10.1016/j.scr.2020.102070

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