Establishment of an induced pluripotent stem cell line (ICGi026-A) from peripheral blood mononuclear cells of a patient with fragile X syndrome
Summary
Expansion over 200 CGG repeats in FMR1 gene causes inherited intellectual disability or autism spectrum disorder named as fragile X syndrome. Despite the known cause fragile X syndrome pathogenesis has not been specified yet. The ICGi026-A iPSCs line was obtained by the reprogramming of the peripheral blood mononuclear cells from a 9-year-old boy with fragile X syndrome. The ICGi026-A iPSCs expressed pluripotency markers, had a normal male karyotype (46, XY) and had the capacity to in vivo differentiate into the cells of three germ layers. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Gridina MM, Orlova PA, Minina JM, Shitik EM, Lemskaya NA, Grishchenko IV, Dolskiy AA, Shorina AR, Maksimova YV, Yudkin DV, Serov OL |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Dec;49:102070 |
| PubMed | 33189043 |
| DOI | 10.1016/j.scr.2020.102070 |