AAKIPSi002-A

General

Cell Line

hPSCreg name AAKIPSi002-A
Cite as:
AAKIPSi002-A (RRID:CVCL_A5PK)
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
AAKIPSi001-A
Donor diseases:
Aniridia
AAKIPSi003-A
Donor diseases:
Aniridia
KSCBi011-A
(DKHi090-A, DKH090i-A)
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Leber Congenital Amaurosis
BIOi003-A
(LYN-C1-P6)
Donor's gene variants:
ABCA4, ABCA4
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Hereditary Retinal Dystrophy
SCTCi015-A
(IPS19-00051)
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Age-Related Macular Degeneration
SCTCi016-A
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CMGANTi005-A
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ESi077-A
(CABi001-A, PRPF31-MiPS4F3)
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PRPF31, PRPF31
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age-related macular degeneration
USPi006-A
(DFNA58-ipsc-dup1-cl2)
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autosomal dominant nonsyndromic deafness 58
USPi007-A
(DFNA58-ipsc-dup2-cl5)
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autosomal dominant nonsyndromic deafness 58
CABi002-A
(OF0176-EYS02-C7, EYS02-MiPS4F7)
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Retinitis Pigmentosa
SCTCi014-A
(IPS17-00056)
Donor diseases:
Age-Related Macular Degeneration
SCTCi012-A
(IPS19-00027)
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age-related macular degeneration
SCTCi013-A
(IPS19-00053)
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age-related macular degeneration
CUIMCi005-A
(BB#2, BB9068#2)
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Stargardt Disease
Last update 26th April 2022
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Provider

Generator INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (AAKIPS)
Owner INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (AAKIPS)
Distributors
Derivation country France

External Databases

BioSamples SAMEA8307196
Cellosaurus CVCL_A5PK
Wikidata Q107113343

General Information

* Is the cell line readily obtainable for third parties?
Yes
Cell line can only be used in: Limbal and corneal commitments
Research use: allowed
Clinical use: not allowed
Commercial use: not allowed

Donor Information

General Donor Information

Sex female

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation and affected.
Synonyms
  • Aniridia

Karyotyping (Donor)

Has the donor karyotype been analysed?
No

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
No

External Databases (Donor)

BioSamples SAMEA8307197

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? Yes
Do you (Depositor/Provider) hold the original Donor Consent Form? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? MESRI
Approval number IE2018-967
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? Yes
Name of accrediting authority involved? MESRI
Approval number IE-2018-967
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes.
Synonyms
  • PERIPHERAL BLOOD MONONUCLEAR CELL
  • Peripheral Blood Mononuclear Cell
  • PBMC

Reprogramming method

Vector type Non-integrating
Vector Sendai virus
Is reprogramming vector detectable?
No
Methods used
PCR, RT-PCR, Sequencing
Files and images showing reprogramming vector expressed or silenced

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Surface coating Laminin
Feeder cells
No
Passage method Mechanically
Medium mTeSR™ 1

Characterisation

Analysis of Undifferentiated Cells

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
No

Other Genotyping (Cell Line)