Generation of an induced pluripotent stem cell line SHCDNi001-A from a one-year-old Chinese girl with mitochondrial DNA depletion syndrome 13
Summary
Mitochondrial DNA depletion syndrome-13 (MTDPS13) is a rare autosomal recessive mitochondrial disease caused by mutations in the FBXL4 (F-box and leucine-rich repeat protein 4) gene. Using Sendai virus-mediated reprogramming, we established an induced pluripotent stem cell (iPSC) line from PBMCs collected from a one-year-old female patient with MTDPS13. The iPSCs were stable during amplification, expressed pluripotent genes, maintained a normal karyotype, and showed characteristics of the three germs layers in an in vitro differentiation assay. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Yuan F, Wang C, Xi J, Wang S, Lin L, Wang Y, Wang A, Wang C, Luo X, Xu Q, Yin R, Cheng H, Zhang Y, Sun X, Chen Y |
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| Journal | Stem cell research |
| Publication Date | 2020 May;45:101832 |
| PubMed | 32416579 |
| DOI | 10.1016/j.scr.2020.101832 |